1-Thioglycerol AR 90% MSDS
Section 1: Chemical Product and Company Identification
Product Name: 1-Thioglycerol AR 90%
Catalog Codes: SLM1210
TSCA: TSCA 8(b) inventory: 1-Thioglycerol AR 90%
CI#: Not available.
Synonym: Thiovanol; 3-Mercapto-1,2-propanediol;
1-Thioglycerol; alpha-Monothioglycerol; alpha-Thioglycerol;
Monothioglycerin; Thioglycerin; Thioglycerol
Chemical Name: 1,2-Propanediol, 3-mercapto-
Chemical Formula: C3-H8-O2-S
Section 2: Composition and Information on Ingredients
Name CAS # % by Weight
Monothioglycerol 96-27-5 100
Toxicological Data on Ingredients: Monothioglycerol: ORAL (LD50): Acute: 670 mg/kg [Rat]. DERMAL (LD50): Acute: 699.3
Section 3: Hazards Identification
Potential Acute Health Effects:
Hazardous in case of skin contact (irritant, permeator), of eye contact (irritant), of inhalation. Slightly hazardous in
case of ingestion.
Potential Chronic Health Effects:
Hazardous in case of skin contact (permeator).
CARCINOGENIC EFFECTS: Not available.
MUTAGENIC EFFECTS: Not available.
TERATOGENIC EFFECTS: Not available.
DEVELOPMENTAL TOXICITY: Not available.
Section 4: First Aid Measures
Check for and remove any contact lenses. In case of contact, immediately flush eyes with plenty of water for at
least 15 minutes. Cold water may be used. WARM water MUST be used. Get medical attention.
In case of contact, immediately flush skin with plenty of water. Cover the irritated skin with an emollient. Remove
contaminated clothing and shoes. Wash clothing before reuse. Thoroughly clean shoes before reuse. Get
Serious Skin Contact:
Wash with a disinfectant soap and cover the contaminated skin with an anti-bacterial cream. Seek immediate
If inhaled, remove to fresh air. If not breathing, give artificial respiration. If breathing is difficult, give oxygen. Get
Serious Inhalation: Not available.
Do NOT induce vomiting unless directed to do so by medical personnel. Never give anything by mouth to an
unconscious person. If large quantities of this material are swallowed, call a physician immediately. Loosen tight
clothing such as a collar, tie, belt or waistband.
Serious Ingestion: Not available.
Section 5: Fire and Explosion Data
Flammability of the Product: May be combustible at high temperature.
Auto-Ignition Temperature: Not available.
Flash Points: CLOSED CUP: >112.78°C (235°F).
Flammable Limits: Not available.
Products of Combustion: These products are carbon oxides (CO, CO2).
Fire Hazards in Presence of Various Substances:
Slightly flammable to flammable in presence of open flames and sparks, of heat.
Non-flammable in presence of shocks.
Explosion Hazards in Presence of Various Substances:
Risks of explosion of the product in presence of mechanical impact: Not available.
Risks of explosion of the product in presence of static discharge: Not available.
Fire Fighting Media and Instructions:
SMALL FIRE: Use DRY chemical powder.
LARGE FIRE: Use water spray, fog or foam. Do not use water jet.
Special Remarks on Fire Hazards:
When heated to decomposition it emits toxic fumes.
Container may rupture from gas generation during a fire situation. Violent stream generation or eruption may
occur upon application of direct water stream to hot liquids.
Special Remarks on Explosion Hazards: Not available.
Section 6: Accidental Release Measures
Small Spill: Absorb with an inert material and put the spilled material in an appropriate waste disposal.
Absorb with an inert material and put the spilled material in an appropriate waste disposal. Finish cleaning by
spreading water on the contaminated surface and allow to evacuate through the sanitary system.
Section 7: Handling and Storage
Keep away from heat. Keep away from sources of ignition. Empty containers pose a fire risk, evaporate the
residue under a fume hood. Ground all equipment containing material. Do not ingest. Do not breathe gas/fumes/
vapor/spray. Wear suitable protective clothing. In case of insufficient ventilation, wear suitable respiratory
equipment. If ingested, seek medical advice immediately and show the container or the label. Avoid contact with
skin and eyes. Keep away from incompatibles such as oxidizing agents, metals, acids.
Storage: Keep container tightly closed. Keep container in a cool, well-ventilated area.
Section 8: Exposure Controls/Personal Protection
Provide exhaust ventilation or other engineering controls to keep the airborne concentrations of vapors below their
respective threshold limit value. Ensure that eyewash stations and safety showers are proximal to the
Splash goggles. Lab coat. Vapor respirator. Be sure to use an approved/certified respirator or equivalent.
Personal Protection in Case of a Large Spill:
Splash goggles. Full suit. Vapor respirator. Boots. Gloves. A self contained breathing apparatus should be
used to avoid inhalation of the product. Suggested protective clothing might not be sufficient; consult a specialist
BEFORE handling this product.
Exposure Limits: Not available.
Section 9: Physical and Chemical Properties
Physical state and appearance: Liquid. (Viscous liquid.)
Odor: Sulfidic (Slight.)
Taste: Not available.
Molecular Weight: 108.15 g/mole
Color: Colorless to light yellow.
pH (1% soln/water): Not available.
Boiling Point: 118°C (244.4°F)
Melting Point: Not available.
Critical Temperature: Not available.
Specific Gravity: 1.295 (Water = 1)
Vapor Pressure: Not available.
Vapor Density: Not available.
Volatility: Not available.
Odor Threshold: Not available.
Water/Oil Dist. Coeff.: Not available.
Ionicity (in Water): Not available.
Dispersion Properties: See solubility in water, acetone.
Easily soluble in acetone.
Slightly soluble in cold water.
Insoluble in diethyl ether.
Slightly soluble in benzene.
Miscible with alcohol.
Section 10: Stability and Reactivity Data
Stability: The product is stable.
Instability Temperature: Not available.
Conditions of Instability:
Excess heat (Avoid temperatures above 120 C. Product can decompose at elevated temperatures), incompatible
Incompatibility with various substances: Reactive with oxidizing agents, metals, acids.
Corrosivity: Non-corrosive in presence of glass.
Special Remarks on Reactivity:
Avoid contact with oxidizing materials. Reactions with oxidizers can be violent.
Avoid contact with metals such as carbon steel.
Avoid unintended contact with strong acids.
Special Remarks on Corrosivity: Not available.
Polymerization: Will not occur.
Section 11: Toxicological Information
Routes of Entry: Absorbed through skin. Dermal contact. Eye contact. Ingestion.
Toxicity to Animals:
Acute oral toxicity (LD50): 670 mg/kg [Rat].
Acute dermal toxicity (LD50): 699.3 mg/kg [Rabbit].
Chronic Effects on Humans: Not available.
Other Toxic Effects on Humans:
Hazardous in case of skin contact (irritant, permeator), of inhalation.
Slightly hazardous in case of ingestion.
Special Remarks on Toxicity to Animals: Not available.
Special Remarks on Chronic Effects on Humans:
May affect genetic material (mutagenic).
May cause adverse reproductive effects based on animal test data. No human data found
Special Remarks on other Toxic Effects on Humans:
Potential Health Effects:
Skin: Prolonged or repeated exposure may cause severe skin irritation. A single prolonged exposure may result
in the material being absorbed in harmul amounts. Prolonged or repeated skin contact which causes the material
to be absorbed through the skin may affect the thyroid.
Eyes: May cause moderate eye irritation. Corneal injury is unlikely.
Inhalation: Mists may cause irritation of the upper respiratory tract (nose and throat). Symptoms may include
burning senstation, coughing, wheezing, laryngitis, shortness of breath, headache, nausea, and vomiting.
Ingestion: Single dose oral toxicity is considered to be low. Small amounts swallowed incidental to normal
handling operations are not likely to cause injury; swallowing amounts larger than that may cause injury. May
cause nausea and vomiting. May affect behavior/central nervous system (convulsions, ataxia). Prolonged or
repeated ingestion may affect thyroid.
Section 12: Ecological Information
Ecotoxicity: Not available.
BOD5 and COD: Not available.
Products of Biodegradation:
Possibly hazardous short term degradation products are not likely. However, long term degradation products may
Toxicity of the Products of Biodegradation: The products of degradation are less toxic than the product itself.
Special Remarks on the Products of Biodegradation: Not available.
Section 13: Disposal Considerations
Waste must be disposed of in accordance with federal, state and local environmental
Section 14: Transport Information
DOT Classification: CLASS 6.1: Poisonous material.
Identification: : Toxic Liquid, organic, n.o.s. (Monothioglycerol) UNNA: 2810 PG: III
Special Provisions for Transport: Not available.
Section 15: Other Regulatory Information
Federal and State Regulations: TSCA 8(b) inventory: Monothioglycerol
OSHA: Hazardous by definition of Hazard Communication Standard (29 CFR 1910.1200).
EINECS: This product is on the European Inventory of Existing Commercial Chemical Substances.
WHMIS (Canada): CLASS D-1B: Material causing immediate and serious toxic effects (TOXIC).
R21/22- Harmful in contact with skin
and if swallowed.
R36/38- Irritating to eyes and skin.
S36/37/39- Wear suitable protective clothing,
gloves and eye/face protection.
S46- If swallowed, seek medical advice
immediately and show this container or label.
Health Hazard: 2
Fire Hazard: 1
Personal Protection: h
National Fire Protection Association (U.S.A.):
Vapor respirator. Be sure to use an
approved/certified respirator or
equivalent. Wear appropriate respirator
when ventilation is inadequate.
Section 16: Other Information
References: Not available.
Other Special Considerations: Not available.
Created: 10/10/2005 10:52 AM
Last Updated: 11/06/2008 12:00 PM