Ethyl Chloroacetate For Synthesis MSDS
Section 1: Chemical Product and Company Identification
Product Name: Ethyl Chloroacetate For Synthesis
Catalog Codes: SLE1066
TSCA: TSCA 8(b) inventory: Ethyl Chloroacetate
CI#: Not available.
Synonym: Chloroacetic Acid, ethyl ester; Ethyl
alpha-chloroacetate; Ethyl chloroethanoate; Ethyl
monochloracetate; Ethyl monochloroacetate
Chemical Name: Acetic acid, chloro-, ethyl ester
Chemical Formula: C4-H7-Cl-O2
Section 2: Composition and Information on Ingredients
Name CAS # % by Weight
Ethyl Chloroacetate 105-39-5 100
Toxicological Data on Ingredients: Ethyl Chloroacetate: ORAL (LD50): Acute: 180 mg/kg [Rat]. 350 mg/kg [Mouse].
DERMAL (LD50): Acute: 161 mg/kg [Rat]. 230 mg/kg [Rabbit]. VAPOR (LC50): Acute: 3.3 mg/m 4 hours [Rat].
Section 3: Hazards Identification
Potential Acute Health Effects:
Hazardous in case of skin contact (irritant), of eye contact (irritant), of ingestion, of inhalation. Severe
over-exposure can result in death.
Potential Chronic Health Effects:
CARCINOGENIC EFFECTS: Not available.
MUTAGENIC EFFECTS: Not available.
TERATOGENIC EFFECTS: Not available.
DEVELOPMENTAL TOXICITY: Not available.
The substance may be toxic to lungs, upper respiratory tract.
Repeated or prolonged exposure to the substance can produce target organs damage. Repeated exposure to a
highly toxic material may produce general deterioration of health by an accumulation in one or many human
Section 4: First Aid Measures
Check for and remove any contact lenses. In case of contact, immediately flush eyes with plenty of water for at
least 15 minutes. Get medical attention.
In case of contact, immediately flush skin with plenty of water for at least 15 minutes while removing contaminated
clothing and shoes. Cover the irritated skin with an emollient. Wash clothing before reuse. Thoroughly clean
shoes before reuse. Get medical attention immediately.
Serious Skin Contact:
Wash with a disinfectant soap and cover the contaminated skin with an anti-bacterial cream. Seek immediate
If inhaled, remove to fresh air. If not breathing, give artificial respiration. If breathing is difficult, give oxygen. Get
medical attention immediately.
Evacuate the victim to a safe area as soon as possible. Loosen tight clothing such as a collar, tie, belt or
waistband. If breathing is difficult, administer oxygen. If the victim is not breathing, perform mouth-to-mouth
resuscitation. WARNING: It may be hazardous to the person providing aid to give mouth-to-mouth resuscitation
when the inhaled material is toxic, infectious or corrosive. Seek immediate medical attention.
If swallowed, do not induce vomiting unless directed to do so by medical personnel. Never give anything by
mouth to an unconscious person. Loosen tight clothing such as a collar, tie, belt or waistband. Get medical
Serious Ingestion: Not available.
Section 5: Fire and Explosion Data
Flammability of the Product: Flammable.
Auto-Ignition Temperature: Not available.
Flash Points: OPEN CUP: 64°C (147.2°F).
Flammable Limits: Not available.
Products of Combustion: These products are carbon oxides (CO, CO2), halogenated compounds.
Fire Hazards in Presence of Various Substances: Flammable in presence of open flames and sparks, of heat.
Explosion Hazards in Presence of Various Substances:
Risks of explosion of the product in presence of mechanical impact: Not available.
Risks of explosion of the product in presence of static discharge: Not available.
Fire Fighting Media and Instructions:
Flammable liquid, insoluble in water.
SMALL FIRE: Use DRY chemical powder.
LARGE FIRE: Use water spray or fog. Never direct a water jet in the container in order to prevent any splashing
of the product which could cause spreading of the fire. Cool containing vessels with water jet in order to prevent
pressure build-up, autoignition or explosion.
Special Remarks on Fire Hazards: When heated to decomposition it emits highly toxic fumes.
Special Remarks on Explosion Hazards: Not available.
Section 6: Accidental Release Measures
Small Spill: Absorb with an inert material and put the spilled material in an appropriate waste disposal.
Toxic flammable liquid, insoluble or very slightly soluble in water. Poisonous liquid.
Keep away from heat. Keep away from sources of ignition. Stop leak if without risk. Absorb with DRY earth,
sand or other non-combustible material. Do not get water inside container. Do not touch spilled material. Use
water spray to reduce vapors. Prevent entry into sewers, basements or confined areas; dike if needed. Call for
assistance on disposal.
Section 7: Handling and Storage
Keep away from heat. Keep away from sources of ignition. Ground all equipment containing material. Do not
ingest. Do not breathe gas/fumes/ vapor/spray. Wear suitable protective clothing. In case of insufficient
ventilation, wear suitable respiratory equipment. If ingested, seek medical advice immediately and show the
container or the label. Avoid contact with skin and eyes. Keep away from incompatibles such as oxidizing agents,
reducing agents, acids, alkalis.
Store in a segregated and approved area. Keep container in a cool, well-ventilated area. Keep container tightly
closed and sealed until ready for use. Avoid all possible sources of ignition (spark or flame). Moisture sensitive.
Section 8: Exposure Controls/Personal Protection
Provide exhaust ventilation or other engineering controls to keep the airborne concentrations of vapors below their
respective threshold limit value. Ensure that eyewash stations and safety showers are proximal to the
Splash goggles. Lab coat. Vapor respirator. Be sure to use an approved/certified respirator or equivalent.
Personal Protection in Case of a Large Spill:
Splash goggles. Full suit. Vapor respirator. Boots. Gloves. A self contained breathing apparatus should be
used to avoid inhalation of the product. Suggested protective clothing might not be sufficient; consult a specialist
BEFORE handling this product.
Exposure Limits: Not available.
Section 9: Physical and Chemical Properties
Physical state and appearance: Liquid.
Odor: Fruity. Pungent.
Taste: Not available.
Molecular Weight: 122.56 g/mole
pH (1% soln/water): Not applicable.
Boiling Point: 144°C (291.2°F) - 146 C
Melting Point: -26°C (-14.8°F)
Critical Temperature: 344.85°C (652.7°F)
Specific Gravity: 1.1498 (Water = 1)
Vapor Pressure: 0.6 kPa (@ 25°C)
Vapor Density: 4.23 - 4.46 (Air = 1)
Volatility: Not available.
Odor Threshold: Not available.
Water/Oil Dist. Coeff.: The product is more soluble in oil; log(oil/water) = 0.9
Ionicity (in Water): Not available.
Dispersion Properties: See solubility in water, diethyl ether, acetone.
Miscible in diethyl ether, acetone.
Insoluble in cold water, hot water.
Miscible with alcohol, ethanol.
Section 10: Stability and Reactivity Data
Stability: The product is stable.
Instability Temperature: Not available.
Conditions of Instability: Heat, ignition sources, incompatible materials
Incompatibility with various substances: Reactive with oxidizing agents, reducing agents, acids, alkalis.
Corrosivity: Not available.
Special Remarks on Reactivity:
Can react vigorously with oxidizing materials.
Will react with water or steam to produce toxic and corrosiive fumes.
Vigorous reaction with sodium cyanide.
When heated to decomposition, it emits highly toxic fumes of hydrogen chloride. Moisture sensitive
Special Remarks on Corrosivity: Not available.
Polymerization: Will not occur.
Section 11: Toxicological Information
Routes of Entry: Absorbed through skin. Eye contact. Inhalation. Ingestion.
Toxicity to Animals:
WARNING: THE LC50 VALUES HEREUNDER ARE ESTIMATED ON THE BASIS OF A 4-HOUR EXPOSURE.
Acute oral toxicity (LD50): 180 mg/kg [Rat].
Acute dermal toxicity (LD50): 161 mg/kg [Rat].
Acute toxicity of the vapor (LC50): 3.3 mg/m3 4 hours [Rat].
Chronic Effects on Humans: May cause damage to the following organs: lungs, upper respiratory tract.
Other Toxic Effects on Humans: Hazardous in case of skin contact (irritant), of ingestion, of inhalation.
Special Remarks on Toxicity to Animals: Not available.
Special Remarks on Chronic Effects on Humans: Not available.
Special Remarks on other Toxic Effects on Humans:
Acute Potential Health Effects:
Skin: Causes skin irritation. It can be absorbed through the skin in harmful amounts and cause systemic effects
similar to inhalation and ingestion.
Eyes: Causes severe eye irritation. It is a lacrimator. May cause conjunctivitis or eye damage.
Inhalation: Harmful if inhaled. Causes respiratory tract irritation (nose, throat), and mucous membrane irritation
with coughing and wheezing. Vapors may cause headache, nausea, dizziness, tremor, or suffocation. Breathing
Ethyl chloroacetate can also irritate the lungs causing coughing and/or shortness of breath (dyspnea) or
respiratory stimulation. Higher exposures can also cause a build-up of fluid in the lungs (pulmonary edema)
Ingestion: Harmful if swallowed. Causes digestive tract (mouth, stomach)irritation with nausea, vomiting,
headache. May affect behavior may affect behavior/central nervous system (somnolence, ataxia, hallucinations,
flaccid paralysis without anesthesia, tremor, dizziness).
Section 12: Ecological Information
Ecotoxicity: Not available.
BOD5 and COD: Not available.
Products of Biodegradation:
Possibly hazardous short term degradation products are not likely. However, long term degradation products may
Toxicity of the Products of Biodegradation: The products of degradation are as toxic as the product itself.
Special Remarks on the Products of Biodegradation: Not available.
Section 13: Disposal Considerations
Waste must be disposed of in accordance with federal, state and local environmental
Section 14: Transport Information
CLASS 3: Flammable liquid.
CLASS 6.1: Poisonous material.
Identification: : Ethyl Chloroacetate UNNA: 1181 PG: II
Special Provisions for Transport: Not available.
Section 15: Other Regulatory Information
Federal and State Regulations:
Connecticut hazardous material survey.: Ethyl Chloroacetate
Pennsylvania RTK: Ethyl Chloroacetate
Florida: Ethyl Chloroacetate
Massachusetts RTK: Ethyl Chloroacetate
Massachusetts spill list: Ethyl Chloroacetate
New Jersey: Ethyl Chloroacetate
TSCA 8(b) inventory: Ethyl Chloroacetate
OSHA: Hazardous by definition of Hazard Communication Standard (29 CFR 1910.1200).
EINECS: This product is on the European Inventory of Existing Commercial Chemical Substances.
WHMIS (Canada): CLASS B-2: Flammable liquid with a flash point lower than 37.8°C (100°F).
R23/24/25- Toxic by inhalation, in
contact with skin and if swallowed.
R50- Very toxic to aquatic organisms.
S7/9- Keep container tightly closed and in a
S16- Keep away from sources of ignition - No
S33- Take precautionary measures against
S45- In case of accident or if you feel unwell,
seek medical advice immediately (show the
label where possible).
S61- Avoid release to the environment. Refer to
special instructions/Safety data sheets.
Health Hazard: 2
Fire Hazard: 2
Personal Protection: h
National Fire Protection Association (U.S.A.):
Vapor respirator. Be sure to use an
approved/certified respirator or
equivalent. Wear appropriate respirator
when ventilation is inadequate.
Section 16: Other Information
-Manufacturer's Material Safety Data Sheet.
Registery of Toxic Effects of Chemical Substances (RTECS).
National Fire Protection Association (NFPA).
Hazardous Substance Data Bank (HSDB)
Other Special Considerations: Not available.
Created: 10/11/2005 11:55 AM
Last Updated: 11/06/2008 12:00 PM