Isopropylamine For Synthesis MSDS
Section 1: Chemical Product and Company Identification
Product Name: Isopropylamine For Synthesis
Catalog Codes: SLI1618
TSCA: TSCA 8(b) inventory: Isopropylamine For Synthesis
CI#: Not available.
Synonym: 2-Aminopropane; Monoisopropylamine;
iso-Propylamine; 1-Methylethylamine; 2-propanimine;
Chemical Name: Isopropylamine
Chemical Formula: C3-H9-N
Section 2: Composition and Information on Ingredients
Name CAS # % by Weight
Isopropylamine 75-31-0 100
Toxicological Data on Ingredients: Isopropylamine: ORAL (LD50): Acute: 111 mg/kg [Rat (RTECS, National Technical
Information Service)]. 2200 mg/kg [Mouse]. 820 mg/kg [Rat (LOLI, Merck Index)]. DERMAL (LD50): Acute: 380 mg/kg [Rabbit].
VAPOR (LC50): Acute: 4000 ppm 4 hours [Rat].
Section 3: Hazards Identification
Potential Acute Health Effects:
Very hazardous in case of skin contact (corrosive, irritant), of eye contact (irritant, corrosive), of ingestion, .
Hazardous in case of inhalation (lung irritant). Slightly hazardous in case of skin contact (sensitizer, permeator).
Liquid or spray mist may produce tissue damage particularly on mucous membranes of eyes, mouth and
respiratory tract. Skin contact may produce burns. Inhalation of the spray mist may produce severe irritation of
respiratory tract, characterized by coughing, choking, or shortness of breath. Severe over-exposure can result in
death. Inflammation of the eye is characterized by redness, watering, and itching. Skin inflammation is
characterized by itching, scaling, reddening, or, occasionally, blistering.
Potential Chronic Health Effects:
CARCINOGENIC EFFECTS: Not available.
MUTAGENIC EFFECTS: Not available.
TERATOGENIC EFFECTS: Not available.
DEVELOPMENTAL TOXICITY: Not available.
The substance may be toxic to upper respiratory tract, skin, eyes, central nervous system (CNS).
Repeated or prolonged exposure to the substance can produce target organs damage. Repeated or prolonged
contact with spray mist may produce chronic eye irritation and severe skin irritation. Repeated or prolonged
exposure to spray mist may produce respiratory tract irritation leading to frequent attacks of bronchial infection.
Repeated exposure to a highly toxic material may produce general deterioration of health by an accumulation in
one or many human organs.
Section 4: First Aid Measures
Check for and remove any contact lenses. In case of contact, immediately flush eyes with plenty of water for at
least 15 minutes. Cold water may be used. Get medical attention immediately.
In case of contact, immediately flush skin with plenty of water for at least 15 minutes while removing contaminated
clothing and shoes. Cover the irritated skin with an emollient. Cold water may be used.Wash clothing before
reuse. Thoroughly clean shoes before reuse. Get medical attention immediately.
Serious Skin Contact:
Wash with a disinfectant soap and cover the contaminated skin with an anti-bacterial cream. Seek immediate
If inhaled, remove to fresh air. If not breathing, give artificial respiration. If breathing is difficult, give oxygen. Get
Evacuate the victim to a safe area as soon as possible. Loosen tight clothing such as a collar, tie, belt or
waistband. If breathing is difficult, administer oxygen. If the victim is not breathing, perform mouth-to-mouth
resuscitation. WARNING: It may be hazardous to the person providing aid to give mouth-to-mouth resuscitation
when the inhaled material is toxic, infectious or corrosive. Seek immediate medical attention.
If swallowed, do not induce vomiting unless directed to do so by medical personnel. Never give anything by
mouth to an unconscious person. Loosen tight clothing such as a collar, tie, belt or waistband. Get medical
Serious Ingestion: Not available.
Section 5: Fire and Explosion Data
Flammability of the Product: Flammable.
Auto-Ignition Temperature: 402°C (755.6°F)
Flash Points: CLOSED CUP: -35°C (-31°F). OPEN CUP: -15°C (5°F).
Flammable Limits: LOWER: 2% UPPER: 10.4%
Products of Combustion: These products are carbon oxides (CO, CO2).
Fire Hazards in Presence of Various Substances: Extremely flammable in presence of open flames and sparks, of heat.
Explosion Hazards in Presence of Various Substances:
Risks of explosion of the product in presence of mechanical impact: Not available.
Explosive in presence of open flames and sparks, of heat.
Fire Fighting Media and Instructions:
Flammable liquid, soluble or dispersed in water.
SMALL FIRE: Use DRY chemical powder.
LARGE FIRE: Use alcohol foam, water spray or fog. Cool containing vessels with water jet in order to prevent
pressure build-up, autoignition or explosion.
Special Remarks on Fire Hazards:
May be ignited by heat, sparks or flames. Vapors may travel to source of ignition and flash back. Most vapors
are heavier than air. They will spread along ground and collect in low or confined areas (sewers, basements,
Special Remarks on Explosion Hazards:
Reacts with perchloryl fluoride to form an explosive mixture.
Vapor explosion hazard indoors, outdoors or in sewers. Run off to sewers may create a fire or explosion hazard.
Containers may explode when heated.
Section 6: Accidental Release Measures
Dilute with water and mop up, or absorb with an inert dry material and place in an appropriate waste disposal
Flammable liquid. Corrosive liquid. Poisonous liquid.
Keep away from heat. Keep away from sources of ignition. Stop leak if without risk. Absorb with DRY earth,
sand or other non-combustible material. Do not get water inside container. Do not touch spilled material. Use
water spray curtain to divert vapor drift. Use water spray to reduce vapors. Prevent entry into sewers,
basements or confined areas; dike if needed. Call for assistance on disposal. Be careful that the product is not
present at a concentration level above TLV. Check TLV on the MSDS and with local authorities.
Section 7: Handling and Storage
Keep locked up.. Keep container dry. Keep away from heat. Keep away from sources of ignition. Ground all
equipment containing material. Do not ingest. Do not breathe gas/fumes/ vapor/spray. Never add water to this
product. In case of insufficient ventilation, wear suitable respiratory equipment. If ingested, seek medical advice
immediately and show the container or the label. Avoid contact with skin and eyes. Keep away from
incompatibles such as oxidizing agents, acids.
Store in a segregated and approved area. Keep container in a cool, well-ventilated area. Keep container tightly
closed and sealed until ready for use. Avoid all possible sources of ignition (spark or flame). Do not store above
Section 8: Exposure Controls/Personal Protection
Provide exhaust ventilation or other engineering controls to keep the airborne concentrations of vapors below their
respective threshold limit value. Ensure that eyewash stations and safety showers are proximal to the
Face shield. Full suit. Vapor respirator. Be sure to use an approved/certified respirator or equivalent. Gloves.
Personal Protection in Case of a Large Spill:
Splash goggles. Full suit. Vapor respirator. Boots. Gloves. A self contained breathing apparatus should be
used to avoid inhalation of the product. Suggested protective clothing might not be sufficient; consult a specialist
BEFORE handling this product.
TWA: 5 STEL: 10 (ppm) from ACGIH (TLV) [United States] 
TWA: 12 STEL: 24 (mg/m3) [Australia]
TWA: 12 STEL: 24 (mg/m3) from ACGIH (TLV) [United States] 
TWA: 12 STEL: 24 (mg/m3) from OSHA (PEL) [United States]
TWA: 12 STEL: 24 (mg/m3) [Canada]Consult local authorities for acceptable exposure limits.
Section 9: Physical and Chemical Properties
Physical state and appearance: Liquid.
Taste: Not available.
Molecular Weight: 59.1 g/mole
pH (1% soln/water): Not available.
Boiling Point: 33.5°C (92.3°F)
Melting Point: -101°C (-149.8°F)
Critical Temperature: 202°C (395.6°F)
Specific Gravity: 0.694 (Water = 1)
Vapor Pressure: 61.3 kPa (@ 20°C)
Vapor Density: 2.04 (Air = 1)
Volatility: Not available.
Odor Threshold: Not available.
Water/Oil Dist. Coeff.: The product is more soluble in oil; log(oil/water) = 0.3
Ionicity (in Water): Not available.
Dispersion Properties: See solubility in water, acetone.
Easily soluble in acetone.
Soluble in cold water.
Section 10: Stability and Reactivity Data
Stability: The product is stable.
Instability Temperature: Not available.
Conditions of Instability: incompatible materials, ignition sources (sparks), heat (high temperatures), mechanical shock
Incompatibility with various substances: Reactive with oxidizing agents, acids.
Corrosivity: Corrosive in presence of aluminum, of zinc, of copper.
Special Remarks on Reactivity:
Incompatible with aldehydes, ketones, epoxides, 1,3-epoxypropane, perchloryl fluoride, acid chlorides, acid
anhydrides, mineral acids, organic acids, sodium hypochlorite, calcium hypochlorite, copper, aluminum, zinc,
galvanized surfaces, peroxides, halogenated agents.
In absence of diluents, contact with most aliphatic or non-aromatic heterocyclic amines often leads to uncontrolled
oxidation or explosions.
Special Remarks on Corrosivity: Corrosive to copper, aluminum, zinc, galvanized surfaces
Polymerization: Will not occur.
Section 11: Toxicological Information
Routes of Entry: Absorbed through skin. Eye contact. Inhalation.
Toxicity to Animals:
WARNING: THE LC50 VALUES HEREUNDER ARE ESTIMATED ON THE BASIS OF A 4-HOUR EXPOSURE.
Acute oral toxicity (LD50): 111 mg/kg [Rat (RTECS, National Technical Information Service)].
Acute dermal toxicity (LD50): 380 mg/kg [Rabbit].
Acute toxicity of the vapor (LC50): 4000 4 hours [Rat].
Chronic Effects on Humans: May cause damage to the following organs: upper respiratory tract, skin, eyes, central nervous
Other Toxic Effects on Humans:
Very hazardous in case of skin contact (corrosive, irritant), of eye contact (corrosive), of ingestion, .
Hazardous in case of inhalation (lung irritant).
Slightly hazardous in case of skin contact (sensitizer, permeator).
Special Remarks on Toxicity to Animals: Harmful to aquatic life in very low concentrations.
Special Remarks on Chronic Effects on Humans: Not available.
Special Remarks on other Toxic Effects on Humans:
Acute Potential Health Effects:
Skin: Harmful if absorbed through skin. May cause skin sensitization, an allergic reaction, which becomes
evident upon reexposure to this material. Causes severe skin irritation and burns.
Eye: May cause 'blue haze' or 'halo' vision. Causes eye irritaiton and burns. May cause lacrimation,
conjunctivitis, and corneal edema when vapor is absorbed into the tissue of the eye. Direct contact with liquid
may cause blindness or permanent eye damage.
Ingestion: May be harmful if swallowed. Causes gastrointestinal tract burns. May affect metabolsim. May cause
central nervous system depression, headache, dizziness, drowsiness and nausea. Advanced stages may cause
collapse, unconsciousness, coma and possible death due to respiratory failure.
Inhalation: Inhalation of high concentrations may cause central nervous system effects (headache, dizziness,
unconsciousness and coma), narcotic effects, delayed pulmonary edema. Causes respiratory tract irritation with
Chronic Potential Health Effects:
Prolonged or repeated skin contact may cause dermatitis.
Section 12: Ecological Information
Ecotoxicity in water (EC50): 91.5 mg/l 48 hours [Daphnia]. Harmful to aquatic life in very low concentrations.
Waste from this product may present long-term environmental hazards.
BOD5 and COD: Not available.
Products of Biodegradation:
Possibly hazardous short term degradation products are not likely. However, long term degradation products may
Toxicity of the Products of Biodegradation: The products of degradation are less toxic than the product itself.
Special Remarks on the Products of Biodegradation: Not available.
Section 13: Disposal Considerations
Section 14: Transport Information
CLASS 3: Flammable liquid.
Class 8: Corrosive material
Identification: : Isopropylamine UNNA: 1221 PG: I
Special Provisions for Transport: Not available.
Section 15: Other Regulatory Information
Federal and State Regulations:
Rhode Island RTK hazardous substances: Isopropylamine
Pennsylvania RTK: Isopropylamine
Massachusetts RTK: Isopropylamine
New Jersey: Isopropylamine
California Director's List of Hazardous Substances (8 CCR 339): Isopropylamine
TSCA 8(b) inventory: Isopropylamine
OSHA: Hazardous by definition of Hazard Communication Standard (29 CFR 1910.1200).
EINECS: This product is on the European Inventory of Existing Commercial Chemical Substances.
CLASS B-2: Flammable liquid with a flash point lower than 37.8°C (100°F).
CLASS D-1B: Material causing immediate and serious toxic effects (TOXIC).
CLASS E: Corrosive liquid.
R12- Extremely flammable.
R36/37/38- Irritating to eyes,
respiratory system and skin.
S16- Keep away from sources of ignition - No
S26- In case of contact with eyes, rinse
immediately with plenty of water and seek
S29- Do not empty into drains.
Health Hazard: 3
Fire Hazard: 4
National Fire Protection Association (U.S.A.):
Vapor respirator. Be sure to use an
approved/certified respirator or
equivalent. Wear appropriate respirator
when ventilation is inadequate.
Section 16: Other Information
References: Not available.
Other Special Considerations: Not available.
Created: 10/11/2005 12:10 PM
Last Updated: 11/06/2008 12:00 PM