Isopropylamine For Synthesis MSDS


Section 1: Chemical Product and Company Identification

Product Name: Isopropylamine For Synthesis

Catalog Codes: SLI1618

CAS#: 75-31-0

RTECS: NT8400000

TSCA: TSCA 8(b) inventory: Isopropylamine For Synthesis

CI#: Not available.

Synonym: 2-Aminopropane; Monoisopropylamine;

iso-Propylamine; 1-Methylethylamine; 2-propanimine;


Chemical Name: Isopropylamine

Chemical Formula: C3-H9-N


Section 2: Composition and Information on Ingredients


Name CAS # % by Weight

Isopropylamine 75-31-0 100

Toxicological Data on Ingredients: Isopropylamine: ORAL (LD50): Acute: 111 mg/kg [Rat (RTECS, National Technical

Information Service)]. 2200 mg/kg [Mouse]. 820 mg/kg [Rat (LOLI, Merck Index)]. DERMAL (LD50): Acute: 380 mg/kg [Rabbit].

VAPOR (LC50): Acute: 4000 ppm 4 hours [Rat].


Section 3: Hazards Identification

Potential Acute Health Effects:

Very hazardous in case of skin contact (corrosive, irritant), of eye contact (irritant, corrosive), of ingestion, .

Hazardous in case of inhalation (lung irritant). Slightly hazardous in case of skin contact (sensitizer, permeator).

Liquid or spray mist may produce tissue damage particularly on mucous membranes of eyes, mouth and

respiratory tract. Skin contact may produce burns. Inhalation of the spray mist may produce severe irritation of

respiratory tract, characterized by coughing, choking, or shortness of breath. Severe over-exposure can result in

death. Inflammation of the eye is characterized by redness, watering, and itching. Skin inflammation is

characterized by itching, scaling, reddening, or, occasionally, blistering.

Potential Chronic Health Effects:





The substance may be toxic to upper respiratory tract, skin, eyes, central nervous system (CNS).

Repeated or prolonged exposure to the substance can produce target organs damage. Repeated or prolonged

contact with spray mist may produce chronic eye irritation and severe skin irritation. Repeated or prolonged

exposure to spray mist may produce respiratory tract irritation leading to frequent attacks of bronchial infection.

Repeated exposure to a highly toxic material may produce general deterioration of health by an accumulation in

one or many human organs.


Section 4: First Aid Measures

Eye Contact:

Check for and remove any contact lenses. In case of contact, immediately flush eyes with plenty of water for at

least 15 minutes. Cold water may be used. Get medical attention immediately.

Skin Contact:

In case of contact, immediately flush skin with plenty of water for at least 15 minutes while removing contaminated

clothing and shoes. Cover the irritated skin with an emollient. Cold water may be used.Wash clothing before

reuse. Thoroughly clean shoes before reuse. Get medical attention immediately.

Serious Skin Contact:

Wash with a disinfectant soap and cover the contaminated skin with an anti-bacterial cream. Seek immediate

medical attention.


If inhaled, remove to fresh air. If not breathing, give artificial respiration. If breathing is difficult, give oxygen. Get

medical attention.

Serious Inhalation:

Evacuate the victim to a safe area as soon as possible. Loosen tight clothing such as a collar, tie, belt or

waistband. If breathing is difficult, administer oxygen. If the victim is not breathing, perform mouth-to-mouth

resuscitation. WARNING: It may be hazardous to the person providing aid to give mouth-to-mouth resuscitation

when the inhaled material is toxic, infectious or corrosive. Seek immediate medical attention.


If swallowed, do not induce vomiting unless directed to do so by medical personnel. Never give anything by

mouth to an unconscious person. Loosen tight clothing such as a collar, tie, belt or waistband. Get medical

attention immediately.

Serious Ingestion: Not available.


Section 5: Fire and Explosion Data

Flammability of the Product: Flammable.

Auto-Ignition Temperature: 402C (755.6F)

Flash Points: CLOSED CUP: -35C (-31F). OPEN CUP: -15C (5F).

Flammable Limits: LOWER: 2% UPPER: 10.4%

Products of Combustion: These products are carbon oxides (CO, CO2).

Fire Hazards in Presence of Various Substances: Extremely flammable in presence of open flames and sparks, of heat.

Explosion Hazards in Presence of Various Substances:

Risks of explosion of the product in presence of mechanical impact: Not available.

Explosive in presence of open flames and sparks, of heat.

Fire Fighting Media and Instructions:

Flammable liquid, soluble or dispersed in water.

SMALL FIRE: Use DRY chemical powder.

LARGE FIRE: Use alcohol foam, water spray or fog. Cool containing vessels with water jet in order to prevent

pressure build-up, autoignition or explosion.

Special Remarks on Fire Hazards:

May be ignited by heat, sparks or flames. Vapors may travel to source of ignition and flash back. Most vapors

are heavier than air. They will spread along ground and collect in low or confined areas (sewers, basements,


Special Remarks on Explosion Hazards:

Reacts with perchloryl fluoride to form an explosive mixture.

Vapor explosion hazard indoors, outdoors or in sewers. Run off to sewers may create a fire or explosion hazard.

Containers may explode when heated.


Section 6: Accidental Release Measures

Small Spill:

Dilute with water and mop up, or absorb with an inert dry material and place in an appropriate waste disposal


Large Spill:

Flammable liquid. Corrosive liquid. Poisonous liquid.

Keep away from heat. Keep away from sources of ignition. Stop leak if without risk. Absorb with DRY earth,

sand or other non-combustible material. Do not get water inside container. Do not touch spilled material. Use

water spray curtain to divert vapor drift. Use water spray to reduce vapors. Prevent entry into sewers,

basements or confined areas; dike if needed. Call for assistance on disposal. Be careful that the product is not

present at a concentration level above TLV. Check TLV on the MSDS and with local authorities.


Section 7: Handling and Storage


Keep locked up.. Keep container dry. Keep away from heat. Keep away from sources of ignition. Ground all

equipment containing material. Do not ingest. Do not breathe gas/fumes/ vapor/spray. Never add water to this

product. In case of insufficient ventilation, wear suitable respiratory equipment. If ingested, seek medical advice

immediately and show the container or the label. Avoid contact with skin and eyes. Keep away from

incompatibles such as oxidizing agents, acids.


Store in a segregated and approved area. Keep container in a cool, well-ventilated area. Keep container tightly

closed and sealed until ready for use. Avoid all possible sources of ignition (spark or flame). Do not store above

23C (73.4F).


Section 8: Exposure Controls/Personal Protection

Engineering Controls:

Provide exhaust ventilation or other engineering controls to keep the airborne concentrations of vapors below their

respective threshold limit value. Ensure that eyewash stations and safety showers are proximal to the

work-station location.

Personal Protection:

Face shield. Full suit. Vapor respirator. Be sure to use an approved/certified respirator or equivalent. Gloves.


Personal Protection in Case of a Large Spill:

Splash goggles. Full suit. Vapor respirator. Boots. Gloves. A self contained breathing apparatus should be

used to avoid inhalation of the product. Suggested protective clothing might not be sufficient; consult a specialist

BEFORE handling this product.

Exposure Limits:

TWA: 5 STEL: 10 (ppm) from ACGIH (TLV) [United States] [1999]

TWA: 12 STEL: 24 (mg/m3) [Australia]

TWA: 12 STEL: 24 (mg/m3) from ACGIH (TLV) [United States] [1999]

TWA: 12 STEL: 24 (mg/m3) from OSHA (PEL) [United States]

TWA: 12 STEL: 24 (mg/m3) [Canada]Consult local authorities for acceptable exposure limits.


Section 9: Physical and Chemical Properties

Physical state and appearance: Liquid.

Odor: Ammonia-like

Taste: Not available.

Molecular Weight: 59.1 g/mole

Color: Colorless.

pH (1% soln/water): Not available.

Boiling Point: 33.5C (92.3F)

Melting Point: -101C (-149.8F)

Critical Temperature: 202C (395.6F)

Specific Gravity: 0.694 (Water = 1)

Vapor Pressure: 61.3 kPa (@ 20C)

Vapor Density: 2.04 (Air = 1)

Volatility: Not available.

Odor Threshold: Not available.

Water/Oil Dist. Coeff.: The product is more soluble in oil; log(oil/water) = 0.3

Ionicity (in Water): Not available.

Dispersion Properties: See solubility in water, acetone.


Easily soluble in acetone.

Soluble in cold water.


Section 10: Stability and Reactivity Data

Stability: The product is stable.

Instability Temperature: Not available.

Conditions of Instability: incompatible materials, ignition sources (sparks), heat (high temperatures), mechanical shock

Incompatibility with various substances: Reactive with oxidizing agents, acids.

Corrosivity: Corrosive in presence of aluminum, of zinc, of copper.

Special Remarks on Reactivity:

Incompatible with aldehydes, ketones, epoxides, 1,3-epoxypropane, perchloryl fluoride, acid chlorides, acid

anhydrides, mineral acids, organic acids, sodium hypochlorite, calcium hypochlorite, copper, aluminum, zinc,

galvanized surfaces, peroxides, halogenated agents.

In absence of diluents, contact with most aliphatic or non-aromatic heterocyclic amines often leads to uncontrolled

oxidation or explosions.

Special Remarks on Corrosivity: Corrosive to copper, aluminum, zinc, galvanized surfaces

Polymerization: Will not occur.


Section 11: Toxicological Information

Routes of Entry: Absorbed through skin. Eye contact. Inhalation.

Toxicity to Animals:


Acute oral toxicity (LD50): 111 mg/kg [Rat (RTECS, National Technical Information Service)].

Acute dermal toxicity (LD50): 380 mg/kg [Rabbit].

Acute toxicity of the vapor (LC50): 4000 4 hours [Rat].

Chronic Effects on Humans: May cause damage to the following organs: upper respiratory tract, skin, eyes, central nervous

system (CNS).

Other Toxic Effects on Humans:

Very hazardous in case of skin contact (corrosive, irritant), of eye contact (corrosive), of ingestion, .

Hazardous in case of inhalation (lung irritant).

Slightly hazardous in case of skin contact (sensitizer, permeator).

Special Remarks on Toxicity to Animals: Harmful to aquatic life in very low concentrations.

Special Remarks on Chronic Effects on Humans: Not available.

Special Remarks on other Toxic Effects on Humans:

Acute Potential Health Effects:

Skin: Harmful if absorbed through skin. May cause skin sensitization, an allergic reaction, which becomes

evident upon reexposure to this material. Causes severe skin irritation and burns.

Eye: May cause 'blue haze' or 'halo' vision. Causes eye irritaiton and burns. May cause lacrimation,

conjunctivitis, and corneal edema when vapor is absorbed into the tissue of the eye. Direct contact with liquid

may cause blindness or permanent eye damage.

Ingestion: May be harmful if swallowed. Causes gastrointestinal tract burns. May affect metabolsim. May cause

central nervous system depression, headache, dizziness, drowsiness and nausea. Advanced stages may cause

collapse, unconsciousness, coma and possible death due to respiratory failure.

Inhalation: Inhalation of high concentrations may cause central nervous system effects (headache, dizziness,

unconsciousness and coma), narcotic effects, delayed pulmonary edema. Causes respiratory tract irritation with

possible burns.

Chronic Potential Health Effects:

Prolonged or repeated skin contact may cause dermatitis.


Section 12: Ecological Information


Ecotoxicity in water (EC50): 91.5 mg/l 48 hours [Daphnia]. Harmful to aquatic life in very low concentrations.

Waste from this product may present long-term environmental hazards.

BOD5 and COD: Not available.

Products of Biodegradation:

Possibly hazardous short term degradation products are not likely. However, long term degradation products may


Toxicity of the Products of Biodegradation: The products of degradation are less toxic than the product itself.

Special Remarks on the Products of Biodegradation: Not available.


Section 13: Disposal Considerations

Waste Disposal:


Section 14: Transport Information

DOT Classification:

CLASS 3: Flammable liquid.

Class 8: Corrosive material

Identification: : Isopropylamine UNNA: 1221 PG: I

Special Provisions for Transport: Not available.


Section 15: Other Regulatory Information

Federal and State Regulations:

Rhode Island RTK hazardous substances: Isopropylamine

Pennsylvania RTK: Isopropylamine

Minnesota: Isopropylamine

Massachusetts RTK: Isopropylamine

New Jersey: Isopropylamine

California Director's List of Hazardous Substances (8 CCR 339): Isopropylamine

Tennessee: Isopropylamine

TSCA 8(b) inventory: Isopropylamine

Other Regulations:

OSHA: Hazardous by definition of Hazard Communication Standard (29 CFR 1910.1200).

EINECS: This product is on the European Inventory of Existing Commercial Chemical Substances.

Other Classifications:

WHMIS (Canada):

CLASS B-2: Flammable liquid with a flash point lower than 37.8C (100F).

CLASS D-1B: Material causing immediate and serious toxic effects (TOXIC).

CLASS E: Corrosive liquid.


R12- Extremely flammable.

R36/37/38- Irritating to eyes,

respiratory system and skin.

S16- Keep away from sources of ignition - No


S26- In case of contact with eyes, rinse

immediately with plenty of water and seek

medical advice.

S29- Do not empty into drains.

HMIS (U.S.A.):

Health Hazard: 3

Fire Hazard: 4

Reactivity: 0

Personal Protection:

National Fire Protection Association (U.S.A.):

Health: 3

Flammability: 4

Reactivity: 3

Specific hazard:

Protective Equipment:


Full suit.

Vapor respirator. Be sure to use an

approved/certified respirator or

equivalent. Wear appropriate respirator

when ventilation is inadequate.

Face shield.


Section 16: Other Information

References: Not available.

Other Special Considerations: Not available.

Created: 10/11/2005 12:10 PM

Last Updated: 11/06/2008 12:00 PM